Description

(+)-Ethyl (S)-2-Hydroxy-4-Oxo-4-Phenylbutanoate is a high-purity chiral intermediate of significant importance in asymmetric synthesis. This compound matters for its role as a key building block in the production of optically active pharmaceuticals and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop enantiomerically pure products.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the (S)-enantiomer configuration.
• Asymmetric Catalysis Research: Used as a starting material or ligand precursor in academic and industrial research focused on developing new catalytic asymmetric reactions.
• Agrochemical Synthesis: Serves as a building block for creating enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances where optical purity is essential.
• Reference Standard: Utilized as a high-purity analytical standard for method development and quality control in chiral analysis (e.g., HPLC, GC).

Basic Information

Product Name	(+)-Ethyl (S)-2-Hydroxy-4-Oxo-4-Phenylbutanoate
CAS No.	243658-52-8
Molecular Formula	C12H14O4
Molecular Weight	222.24 g/mol
Synonyms	(S)-Ethyl 2-Hydroxy-4-oxo-4-phenylbutanoate; Ethyl (S)-2-Hydroxy-4-oxo-4-phenylbutyrate; (S)-2-Hydroxy-4-oxo-4-phenylbutanoic Acid Ethyl Ester; (S)-HOPBE; (S)-Ethyl 2-Hydroxy-4-oxo-4-phenylbutyrate; (S)-Ethyl 4-Oxo-4-phenyl-2-hydroxybutanoate; (S)-α-Hydroxy-β-oxo-benzenebutanoic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our production of (+)-Ethyl (S)-2-Hydroxy-4-Oxo-4-Phenylbutanoate adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination. Certificates of Analysis (COA) detailing purity, identity, and specific impurities are available upon request, supporting compliance with cGMP and ISO 9001 standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.