Description

tert-Butyl 2-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate CAS NO 241819-85-2 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily needed by pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the production of sophisticated small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its privileged spirocyclic indane-piperidine structure.
• API Synthesis: Serves as a core scaffold in multi-step syntheses for potential treatments in neurology and psychiatry.
• Process Chemistry & Scale-Up: Employed in route scouting and pilot-scale manufacturing of complex target molecules.
• Chemical Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical production.
• Academic & Institutional Research: Facilitates organic synthesis and pharmacological studies in university and institutional settings.

Basic Information

Product Name	tert-Butyl 2-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	241819-85-2
Molecular Formula	C18H23NO3
Molecular Weight	301.38 g/mol
Synonyms	1'-Boc-2-oxo-2,3-dihydrospiro[indene-1,4'-piperidine]; tert-Butyl 2-oxo-1,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate; 1,3-Dihydrospiro[indene-1,4'-piperidin]-2-one 1'-carboxylic acid tert-butyl ester; 2-Oxo-2,3-dihydro-1H-spiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Boc-protected Spirocyclic Piperidine Ketone; Spiro[indene-1,4'-piperidine] Intermediate; CAS 241819-85-2
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Oxo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.