Description

2-(5-Carboxyfurfurylthio)-5-(Trifluoromethyl)Pyridine is a high-value, multi-functional heterocyclic building block featuring both a carboxylic acid and a trifluoromethyl group. This compound is critical for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly due to the advantageous properties imparted by the fluorine atom. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in synthesizing advanced intermediates for drug discovery programs targeting various therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, especially those requiring a trifluoromethylpyridine moiety for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in developing advanced active ingredients for crop protection, where the trifluoromethyl group can improve pesticidal activity and environmental profile.
• Ligand Synthesis: The carboxylic acid functionality allows for its use in constructing complex ligands for catalysis or metal-organic frameworks (MOFs).
• Material Science: Acts as a building block for specialty polymers and advanced organic materials with tailored electronic or surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	2-(5-Carboxyfurfurylthio)-5-(Trifluoromethyl)Pyridine
CAS No.	238742-86-4
Molecular Formula	C12H8F3NO3S
Molecular Weight	303.26 g/mol
Synonyms	5-(Trifluoromethyl)pyridine-2-thiol, 5-carboxy-2-furfuryl ester; 2-[(5-Carboxy-2-furanyl)methyl]thio-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-[[(5-carboxy-2-furanyl)methyl]thio]pyridine; 2-((5-Carboxyfuran-2-yl)methylthio)-5-(trifluoromethyl)pyridine; 2-(5-Carboxy-2-furfurylthio)-5-trifluoromethylpyridine; 238742-86-4; (5-Carboxy-2-furfurylthio)-5-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-(5-Carboxyfurfurylthio)-5-(Trifluoromethyl)Pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere such as nitrogen or argon to preserve stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.