Description

Carbamic Acid, (Trimethylsilyl)-, 1,1-Dimethylethyl Ester (9Ci) is a specialized organosilicon-protected carbamate derivative, serving as a versatile building block and protective group reagent in advanced organic synthesis. Its primary value lies in enabling complex multi-step syntheses by providing a robust, silyl-protected amine functionality that is stable under a wide range of reaction conditions yet can be selectively deprotected. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for the synthesis of novel active ingredients, peptides, and complex natural product analogs where precise control over functional group manipulation is critical.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs), especially in the synthesis of carbamate-based drugs and prodrugs.
• Peptide Synthesis: Used as a protecting group for amino functions during solid-phase and solution-phase peptide synthesis, preventing unwanted side reactions.
• Agrochemical Development: Employed in the research and production of advanced herbicides, fungicides, and insecticides that utilize carbamate chemistry.
• Material Science Research: Acts as a precursor or modifying agent in the development of specialty polymers, silicones, and functionalized surfaces.
• Organic Synthesis Reagent: Facilitates complex multi-step synthetic routes in academic and industrial R&D labs for constructing heterocycles and complex molecular architectures.
• Protecting Group Chemistry: Provides a stable tert-butoxycarbonyl (Boc)-like protection for amines, with the trimethylsilyl group offering unique deprotection profiles.

Basic Information

Item	Details
Product Name	Carbamic Acid, (Trimethylsilyl)-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	238096-95-2
Molecular Formula	C9H21NO2Si
Molecular Weight	203.36 g/mol
Synonyms	tert-Butyl (trimethylsilyl)carbamate; N-(tert-Butoxycarbonyl)-N-(trimethylsilyl)amine; 1,1-Dimethylethyl N-(trimethylsilyl)carbamate; BOC-NH-TMS; (Trimethylsilyl)carbamic Acid tert-Butyl Ester; N-Boc-N-trimethylsilylamine; tert-Butyl (trimethylsilyl)carbamate; N-(tert-Butoxycarbonyl)trimethylsilylamine
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, (Trimethylsilyl)-, 1,1-Dimethylethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR analysis, to confirm identity, potency, and impurity profiles. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP requirements for use as a pharmaceutical intermediate, ensuring traceability and regulatory compliance for global markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.