Description

Lovastatin Ammonium Salt is a high-purity, semi-synthetic derivative of lovastatin, a well-known statin compound. This ammonium salt form offers enhanced solubility and stability, making it a critical intermediate for advanced pharmaceutical research and manufacturing. It is primarily utilized by pharmaceutical companies and research institutions in the development and production of cholesterol-lowering medications and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key starting material or intermediate in the synthesis of active pharmaceutical ingredients (APIs) for statin-based drugs.
• Biochemical Research: Used in laboratory studies to investigate HMG-CoA reductase inhibition, cholesterol biosynthesis pathways, and related metabolic processes.
• Reference Standard: Serves as a certified reference material (CRM) or analytical standard for quality control and method validation in pharmaceutical analysis.
• Formulation Development: Employed in pre-formulation and formulation studies for new drug delivery systems due to its modified physicochemical properties.

Basic Information

Product Name	Lovastatin Ammonium Salt
CAS No.	237073-64-2
Molecular Formula	C24H38NO5 • NH3 (or C24H41N2O5)
Molecular Weight	~ 437.60 g/mol
Synonyms	Lovastatin Ammonium; Monacolin K Ammonium Salt; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate Ammonium Salt; Mevinolinic Acid Ammonium Salt; 6α-Methylcompactin Ammonium Salt
EINECS	Contact for details

Quality Control

Our Lovastatin Ammonium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets stringent standards suitable for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.