Description

Azide-Peg4-Tos is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a reactive azide group and a tosylate leaving group. This compound is essential for creating stable, covalent linkages in bioconjugation and materials science, enabling the precise assembly of complex molecular architectures. It is primarily utilized by researchers and manufacturers in pharmaceutical development, proteomics, and advanced material synthesis.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Used to attach cytotoxic payloads or fluorescent labels to antibodies, proteins, or peptides via click chemistry.
• Polymer and Dendrimer Functionalization: Serves as a key building block for introducing azide functionalities into polymer backbones or dendritic structures for further modification.
• Surface Immobilization and Biochip Fabrication: Enables the covalent attachment of biomolecules (e.g., oligonucleotides, proteins) to surfaces for biosensor and microarray applications.
• Materials Science and Nanotechnology: Facilitates the crosslinking and functionalization of nanoparticles, hydrogels, and other nanomaterials to tailor their properties.
• Chemical Biology and Probe Synthesis: A critical reagent for synthesizing activity-based probes or affinity tags to study enzyme function and protein interactions.
• Diagnostic Reagent Manufacturing: Employed in the production of diagnostic assay components requiring stable, site-specific labeling.

Basic Information

Product Name	Azide-Peg4-Tos
CAS No.	236754-49-7
Molecular Formula	C19H29N5O8S
Molecular Weight	487.53 g/mol
Synonyms	Azido-PEG4-tosylate; 2,5,8,11-Tetraoxatridecan-13-yl 4-methylbenzenesulfonate; 13-Azido-4,7,10-trioxatridecyl 4-methylbenzenesulfonate; PEG4-Azide Tosylate; Azido-PEG4-OTs; N3-PEG4-OTs; Tosyl-PEG4-azide; 4-Methylbenzenesulfonic Acid 13-Azido-4,7,10-trioxatridecyl Ester
EINECS	Contact for details

Quality Control

Our Azide-Peg4-Tos is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.