Description

Bicyclo[3.1.0]Hexane-6-Carboxylic Acid, 3,3-Difluoro-, Ethyl Ester, (1-α-,5-α-,6-α-)- (9Ci) is a high-value, stereochemically defined fluorinated bicyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique rigid scaffold and the strategic introduction of fluorine atoms, which are critical for modulating the physicochemical and biological properties of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients, particularly where metabolic stability and bioavailability are key design parameters.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially in central nervous system (CNS) and antiviral research.
• Agrochemical Development: Used in constructing advanced scaffolds for new generation herbicides and pesticides with enhanced efficacy.
• Material Science Research: Serves as a precursor for specialty monomers or ligands in catalysis due to its strained bicyclic structure.
• Fluorine Chemistry: An essential building block for studying structure-activity relationships (SAR) in medicinal chemistry by introducing a difluoromethylene group.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial production of complex molecules.
• Academic Research: Used in methodological studies and the development of new synthetic transformations involving strained systems.

Basic Information

Product Name	Bicyclo[3.1.0]Hexane-6-Carboxylic Acid, 3,3-Difluoro-, Ethyl Ester, (1-α-,5-α-,6-α-)- (9Ci)
CAS No.	234085-27-9
Molecular Formula	C9H12F2O2
Molecular Weight	190.19 g/mol
Synonyms	Ethyl 3,3-difluorobicyclo[3.1.0]hexane-6-carboxylate; (1α,5α,6α)-Ethyl 3,3-difluorobicyclo[3.1.0]hexane-6-carboxylate; Bicyclo[3.1.0]hexane-6-carboxylic acid, 3,3-difluoro-, ethyl ester, (1α,5α,6α)-; 3,3-Difluorobicyclo[3.1.0]hexane-6-carboxylic acid ethyl ester; Ethyl (1R,5S,6R)-3,3-difluorobicyclo[3.1.0]hexane-6-carboxylate; 234085-27-9; 9CI
EINECS	Contact for details

Quality Control

Our production of Bicyclo[3.1.0]Hexane-6-Carboxylic Acid, 3,3-Difluoro-, Ethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical characterization, including chiral purity verification, to meet exacting customer specifications. Certificates of Analysis (COA) detailing identity, purity (by GC/HPLC), and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.