Description

Pyridine, 3-Fluoro-5-[[(2R)-1-Methyl-2-Azetidinyl]Methoxy]- (9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its specific chiral and fluorinated pyridine structure. This compound is critical for medicinal chemistry research and development, offering a precise building block for creating novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers targeting the synthesis of complex, biologically active molecules, particularly in the areas of central nervous system (CNS) and metabolic disorder therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component in the development of proprietary APIs for clinical trials.
• Preclinical Drug Development: Employed in the synthesis of compounds for pharmacological profiling and toxicology studies.
• Contract Research and Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and scale-up.
• Academic Research: Used in university and institutional labs for cutting-edge research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	Pyridine, 3-Fluoro-5-[[(2R)-1-Methyl-2-Azetidinyl]Methoxy]- (9Ci)
CAS No.	228867-33-2
Molecular Formula	C10H13FN2O
Molecular Weight	196.22 g/mol
Synonyms	3-Fluoro-5-[[(2R)-1-Methyl-2-azetidinyl]methoxy]pyridine; (R)-3-((1-Methylazetidin-2-yl)methoxy)-5-fluoropyridine; 5-Fluoro-3-[[(2R)-1-methyl-2-azetidinyl]methoxy]pyridine; 228867-33-2; (R)-3-Fluoro-5-((1-methylazetidin-2-yl)methoxy)pyridine; Azetidine, 2-[(5-fluoro-3-pyridinyloxy)methyl]-1-methyl-, (2R)-; A fluorinated chiral azetidine-pyridine ether
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical methods including HPLC, GC, NMR, and chiral purity analysis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. We support development under cGMP guidelines as required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Related Substances (HPLC)	Total impurities ≤3.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.