Description

Methyl 2-Nitro-4-(Trifluoromethyl)Benzoate is a high-purity, multi-functional aromatic ester building block featuring both nitro and trifluoromethyl substituents. This compound is essential for advanced organic synthesis, offering a versatile scaffold for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on active ingredient discovery and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a critical building block for developing advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Dye and Pigment Intermediate: Functions as a starting material for synthesizing complex colorants and functional dyes.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Buchwald-Hartwig aminations to create biaryl structures.
• Fluorine Chemistry Studies: A valuable compound for investigating the influence of the trifluoromethyl group on reaction kinetics and molecular properties.

Basic Information

Product Name	Methyl 2-Nitro-4-(Trifluoromethyl)Benzoate
CAS No.	228418-45-9
Molecular Formula	C9H6F3NO4
Molecular Weight	249.14 g/mol
Synonyms	Methyl 2-Nitro-α,α,α-trifluoro-p-toluate; 2-Nitro-4-(trifluoromethyl)benzoic Acid Methyl Ester; Benzoic acid, 2-nitro-4-(trifluoromethyl)-, methyl ester; Methyl 2-nitro-4-trifluoromethylbenzoate; Methyl 4-(Trifluoromethyl)-2-nitrobenzoate; 2-Nitro-4-trifluoromethylbenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Nitro-4-(Trifluoromethyl)Benzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided with each shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.