Description

Ethyl 3,3-Difluoro-1-Methylcyclobutane-1-Carboxylate is a high-value fluorinated cyclobutane derivative, serving as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring a difluorinated cyclobutane ring, is engineered to impart desirable properties such as metabolic stability and enhanced lipophilicity into target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral therapies.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms can improve biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated components in electronic display materials, contributing to improved performance and durability.
• Advanced Polymer Chemistry: Employed to introduce fluorinated cyclobutane units into specialty polymers, enhancing their chemical resistance and thermal properties.
• Chemical Research & Development: Serves as a valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	Ethyl 3,3-Difluoro-1-Methylcyclobutane-1-Carboxylate
CAS No.	227607-45-6
Molecular Formula	C9H14F2O2
Molecular Weight	192.20 g/mol
Synonyms	1-Methyl-3,3-difluorocyclobutane-1-carboxylic acid ethyl ester; Ethyl 1-methyl-3,3-difluorocyclobutane-1-carboxylate; 3,3-Difluoro-1-methylcyclobutane-1-carboxylic Acid Ethyl Ester; 227607-45-6; Ethyl 3,3-difluoro-1-methyl-1-cyclobutanecarboxylate; 1-Cyclobutanecarboxylic acid, 3,3-difluoro-1-methyl-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 3,3-Difluoro-1-Methylcyclobutane-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality protocols to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are properly sealed and stored upright. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.