Description

(S)-Methyl 2-((tert-Butoxycarbonyl)Amino)-2-(4-Hydroxyphenyl)Acetate CAS NO 225517-15-7 is a high-purity, chiral amino acid derivative featuring both a tert-butoxycarbonyl (Boc) protecting group and a phenolic hydroxyl group. This compound is a critical advanced pharmaceutical intermediate (API) used in the synthesis of complex, biologically active molecules. It is essential for research and production in the pharmaceutical and biotechnology sectors, particularly for developing peptide-based therapeutics and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially in peptide and peptidomimetic drug development.
• Protease Inhibitor Synthesis: Used in the research and production of inhibitors targeting enzymes like renin, HIV protease, and other aspartic proteases.
• Peptide Chemistry: Serves as a protected tyrosine analog for solid-phase and solution-phase peptide synthesis (SPPS).
• Chemical Biology Research: Employed as a tool compound for studying protein-protein interactions and signal transduction pathways.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective organic synthesis.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical laboratories.

Basic Information

Product Name	(S)-Methyl 2-((tert-Butoxycarbonyl)Amino)-2-(4-Hydroxyphenyl)Acetate
CAS No.	225517-15-7
Molecular Formula	C14H19NO5
Molecular Weight	281.30 g/mol
Synonyms	(S)-Methyl 2-(Boc-amino)-2-(4-hydroxyphenyl)acetate; (S)-Methyl 2-((Boc)amino)-2-(4-hydroxyphenyl)acetate; (S)-Methyl Boc-tyrosine methyl ester; (S)-Methyl N-Boc-4-hydroxyphenylglycinate; (S)-Methyl N-(tert-Butoxycarbonyl)-4-hydroxyphenylglycinate; (S)-2-((tert-Butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetic acid methyl ester; Boc-Tyr(Me)-OH (common abbreviation); N-Boc-O-methyl-L-tyrosine methyl ester
EINECS	Contact for details

Quality Control

Our (S)-Methyl 2-((tert-Butoxycarbonyl)Amino)-2-(4-Hydroxyphenyl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee batch-to-batch consistency and traceability for your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.