Description

(R)-2,2',3,3'-Tetrahydro-1,1'-Spirobi[Indene]-7,7'-Diol, >=95% is a high-purity, chiral spirobiindane derivative, a crucial building block in asymmetric synthesis. This compound matters for its role as a privileged ligand precursor and chiral auxiliary, enabling the production of enantiomerically pure pharmaceuticals and advanced materials. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require high stereochemical fidelity.

Application

• Asymmetric Catalysis: Serves as a precursor for chiral phosphine or diamine ligands used in transition-metal catalyzed reactions (e.g., hydrogenation, cross-coupling).
• Pharmaceutical Intermediate: A key chiral scaffold in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders and other therapeutic areas.
• Material Science: Used in the development of chiral polymers, liquid crystals, and organic frameworks with specific optical or electronic properties.
• Agrochemical Synthesis: Employed in the research and development of enantiopure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and process optimization.
• Chiral Resolution Agent: Can be utilized in the separation of racemic mixtures via diastereomeric salt formation or as a chiral selector in chromatography.

Basic Information

Product Name	(R)-2,2',3,3'-Tetrahydro-1,1'-Spirobi[Indene]-7,7'-Diol, >=95%
CAS No.	223259-62-9
Molecular Formula	C17H16O2
Molecular Weight	252.31 g/mol
Synonyms	(R)-Spirobiindan-7,7'-diol; (7R,7'R)-7,7'-Dihydroxy-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]; (R)-7,7'-Dihydroxyspirobiindane; (R)-H8-BINOL; (R)-Tetrahydrospirobiindanediol; (R)-Octahydrospirobiindene-7,7'-diol; (R)-Spiro[1H-indene-7,2'-[1,3]dioxolo[4,5-f][1,3]benzodioxole] tetrahydro derivative
EINECS	Contact for details

Quality Control

Our (R)-2,2',3,3'-Tetrahydro-1,1'-Spirobi[Indene]-7,7'-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity (≥95%), and enantiomeric excess meet stringent specifications. Certificates of Analysis (COA) with full traceability are provided to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. Keep the container in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.