Description

(S)-Methyl 2-(Benzenesulfonyloxy)-2-(2-Chlorophenyl)Acetate is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key precursor for constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs) and other fine chemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel compounds and the optimization of production routes.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the research and development of new Active Pharmaceutical Ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders or requiring specific enantiomeric purity.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure pesticides and herbicides, where the specific (S)-configuration can be essential for biological activity and environmental safety.
• Asymmetric Catalysis Research: Serves as a standard substrate or ligand precursor in academic and industrial laboratories for developing and testing new asymmetric synthetic methodologies.
• Fine Chemical Manufacturing: Employed in the multi-step synthesis of complex fragrance molecules, liquid crystals, and other high-value specialty chemicals requiring precise stereocontrol.
• Process Chemistry Development: Utilized for scaling up synthetic routes from laboratory to pilot plant and commercial production, where reliable supply and consistent quality are paramount.

Basic Information

Product Name	(S)-Methyl 2-(Benzenesulfonyloxy)-2-(2-Chlorophenyl)Acetate
CAS No.	223123-46-4
Molecular Formula	C15H13ClO5S
Molecular Weight	340.78 g/mol
Synonyms	(S)-Methyl 2-((Phenylsulfonyl)oxy)-2-(2-chlorophenyl)acetate; Methyl (S)-2-(benzenesulfonyloxy)-2-(2-chlorophenyl)acetate; (S)-Methyl O-(phenylsulfonyl)mandelate, 2'-chloro derivative; (S)-2-(2-Chlorophenyl)-2-((phenylsulfonyl)oxy)acetic acid methyl ester; (S)-Methyl 2-(2-chlorophenyl)-2-((phenylsulfonyl)oxy)acetate; CAS 223123-46-4; (S)-Methyl α-(benzenesulfonyloxy)-2-chlorobenzeneacetate
EINECS	Contact for details

Quality Control

Every batch of (S)-Methyl 2-(Benzenesulfonyloxy)-2-(2-Chlorophenyl)Acetate is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high standards required for pharmaceutical and fine chemical applications. Our commitment includes comprehensive identity confirmation, chiral purity verification, and impurity profiling. Certificates of Analysis (COA) detailing specific results for chiral purity (HPLC), chemical purity (HPLC), and residual solvents (GC) are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep the container tightly sealed under an inert atmosphere if long-term storage is required to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.