Description

Benzoic Acid, 4-[(1S)-1-Aminoethyl]-, Methyl Ester is a chiral, non-proteinogenic amino acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the combination of a protected carboxylic acid group and a primary amine, making it a versatile intermediate for constructing complex molecules with high stereochemical purity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), peptide mimetics, and chiral ligands.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel APIs, especially in oncology, neurology, and metabolic disease research.
• Peptidomimetics & PROTACs: Used in the design and synthesis of peptide analogs and Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Agrochemical Synthesis: Building block for creating chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Asymmetric Catalyst Ligand: Precursor for synthesizing novel chiral ligands used in asymmetric hydrogenation and other catalytic transformations.
• Fine Chemical Production: Intermediate in the multi-step synthesis of specialty dyes, flavors, and fragrances requiring specific stereochemistry.
• Academic & R&D: Serves as a standard or starting material in methodological development and medicinal chemistry programs within research institutions.

Basic Information

Product Name	Benzoic Acid, 4-[(1S)-1-Aminoethyl]-, Methyl Ester
CAS No.	222714-37-6
Molecular Formula	C10H13NO2
Molecular Weight	179.22 g/mol
Synonyms	(S)-Methyl 4-(1-Aminoethyl)benzoate; (S)-Methyl 4-(1-Aminoethyl)benzoate Hydrochloride (common salt form); L-4-(1-Aminoethyl)benzoic Acid Methyl Ester; Methyl (S)-4-(1-Aminoethyl)benzoate; 4-[(1S)-1-Aminoethyl]benzoic Acid Methyl Ester; (S)-1-(4-(Methoxycarbonyl)phenyl)ethan-1-amine; p-[(S)-1-Aminoethyl]benzoic Acid Methyl Ester
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 4-[(1S)-1-Aminoethyl]-, Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the exacting standards required for pharmaceutical and advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Maximum Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.