Description

Spiro[Bicyclo[2.2.1]Heptane-2,5-Oxazolidin]-2-One, 1,7,7-Trimethyl-, (1R,2R,4R)- is a high-value, stereochemically defined chiral building block and organocatalyst. Its unique spirocyclic and oxazolidinone structure makes it a critical intermediate for the synthesis of complex molecules with precise three-dimensional architecture. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in asymmetric synthesis, medicinal chemistry, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Asymmetric Organocatalysis: Serves as a chiral catalyst or catalyst precursor for enantioselective organic transformations.
• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and anti-infective drugs.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to introduce conformational rigidity and chiral centers.
• Advanced Material Synthesis: Potential building block for chiral polymers or liquid crystals with specific optical properties.
• Academic & Industrial R&D: Employed in methodological studies for new synthetic routes and catalysis research.
• Agrochemical Research: Investigated as an intermediate for the synthesis of chiral, biologically active compounds in crop protection.

Basic Information

Product Name	Spiro[Bicyclo[2.2.1]Heptane-2,5-Oxazolidin]-2-One, 1,7,7-Trimethyl-, (1R,2R,4R)-
CAS No.	222178-77-0
Molecular Formula	C11H17NO2
Molecular Weight	195.26 g/mol
Synonyms	(1R,2R,4R)-1,7,7-Trimethylspiro[bicyclo[2.2.1]heptane-2,5'-oxazolidin]-2'-one; (1R,2R,4R)-1,7,7-Trimethyl-2-oxa-5-azaspiro[bicyclo[2.2.1]heptane-3,2'-oxazolidin]-4'-one; (-)-Camphor Derived Spiro Oxazolidinone; Chiral Spirocyclic Oxazolidinone; (1R,2R,4R)-TMSO; Spiro Oxazolidinone Organocatalyst
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥97% (by HPLC) and can offer custom synthesis to meet specific chiral purity (e.g., >99% ee) and analytical requirements. Certificates of Analysis (COA) detailing identity, purity, and chiral excess are available upon request. Production can be aligned with cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage or when working with large quantities.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (typical, custom grades available)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.