Description

Spiro[Pyrrolidine-2,7'(6'H)-[2H]Pyrrolo[2,1-B][1,3]Thiazine]-1,4'-Dicarboxylic Acid, Tetrahydro-6'-Oxo-, 1-(1,1-Dimethylethyl) 4'-Methyl Ester, (2R,4'R,8'Ar)- is a high-purity, stereochemically defined spirocyclic compound that serves as a critical advanced pharmaceutical intermediate. Its complex fused-ring structure makes it a valuable building block for the synthesis of novel, biologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly those focused on creating new therapeutic agents with specific chiral configurations.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for complex small-molecule drugs.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for constructing compound libraries in drug discovery programs targeting new biological pathways.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Synthesis of Chiral Compounds: Exploited for the preparation of enantiomerically pure substances where the specific (2R,4'R,8'Ar) stereochemistry is required for biological activity.
• Chemical Biology Probes: Can be utilized to develop specialized molecular probes for studying enzyme mechanisms or protein interactions.

Basic Information

Product Name	Spiro[Pyrrolidine-2,7'(6'H)-[2H]Pyrrolo[2,1-B][1,3]Thiazine]-1,4'-Dicarboxylic Acid, Tetrahydro-6'-Oxo-, 1-(1,1-Dimethylethyl) 4'-Methyl Ester, (2R,4'R,8'Ar)-
CAS No.	221040-37-5
Molecular Formula	C17H24N2O5S
Molecular Weight	368.45 g/mol
Synonyms	(2R,4'R,8'Ar)-1-(tert-Butyl) 4'-methyl 1,4'-dioxo-1,4',6',7',8',8a'-hexahydrospiro[pyrrolidine-2,2'-[2H]pyrrolo[2,1-b][1,3]thiazine]-1,4'-dicarboxylate; tert-Butyl (2R,4'R,8'Ar)-4'-methoxycarbonyl-6'-oxo-1,4',6',7',8',8a'-hexahydrospiro[pyrrolidine-2,2'-[2H]pyrrolo[2,1-b][1,3]thiazine]-1-carboxylate; CAS 221040-37-5; Spirocyclic Pyrrolo-Thiazine Derivative; (2R,4'R,8aR)-1-(tert-Butoxycarbonyl)-4'-(methoxycarbonyl)-1,4',6',7',8',8a'-hexahydrospiro[pyrrolidine-2,2'-pyrrolo[2,1-b][1,3]thiazine]-6'-one.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Identity, purity, and chiral integrity are verified using advanced analytical techniques including HPLC, GC, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, impurity profile, and stereochemical purity is provided with each batch to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R,4'R,8'Ar) isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.