Description

Valategrast is a potent and selective small-molecule antagonist of the α4β1 integrin (VLA-4), a key target in inflammatory and autoimmune pathways. This compound is of significant interest for its potential in the research and development of novel therapeutics targeting conditions such as asthma, multiple sclerosis, and other inflammatory diseases. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research institutions engaged in immunology and drug discovery.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in preclinical studies for novel anti-inflammatory and immunomodulatory drugs.
• Biochemical Assay Development: Used as a selective tool compound in high-throughput screening (HTS) and in vitro assays to study VLA-4 mediated cell adhesion and signaling pathways.
• Mechanism of Action Studies: Employed in academic and industrial research to elucidate the role of α4β1 integrin in autoimmune disease models, including experimental autoimmune encephalomyelitis (EAE).
• Drug Discovery Pipeline: A key intermediate or target molecule for medicinal chemistry programs aimed at optimizing potency, selectivity, and pharmacokinetic properties of VLA-4 antagonists.
• Inflammation & Immunology Research: Provides a research tool for investigating leukocyte migration and the inflammatory cascade in conditions like asthma and inflammatory bowel disease (IBD).

Basic Information

Product Name	Valategrast
CAS No.	220847-86-9
Molecular Formula	C₂₉H₃₈N₄O₆
Molecular Weight	538.64 g/mol
Synonyms	(2S)-3-[4-({[4-(1,4-Dioxo-1,4-dihydrophthalazin-2-yl)butyl]amino}carbonyl)-2,6-difluorophenyl]-2-[(3-fluorophenyl)sulfonylamino]propanoic Acid; R-411; WAY-103; VLA-4 Antagonist R411; (S)-2-((3-Fluorophenylsulfonamido)-3-(4-((4-(1,4-dioxo-3,4-dihydrophthalazin-2(1H)-yl)butyl)carbamoyl)-2,6-difluorophenyl)propanoic Acid
EINECS	Contact for details

Quality Control

Our Valategrast is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), related substances, and other critical parameters is provided with every shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, ideally between 15-25°C, in a dry environment. Keep the container sealed to protect the material from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.