Description

4-Iodo-Oxazole-5-Carboxylic Acid Ethyl Ester is a high-value, functionalized heterocyclic building block essential for advanced organic synthesis. This compound matters as a versatile intermediate that enables the rapid construction of complex molecular architectures, particularly in pharmaceutical discovery. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting various therapeutic areas.
• Agrochemical Research: Used in the synthesis of new generation herbicides, fungicides, and insecticides with potentially improved efficacy and environmental profiles.
• Material Science: Serves as a precursor for synthesizing specialized polymers, liquid crystals, or organic electronic materials due to its halogenated oxazole core.
• Chemical Biology & Probe Development: Employed in creating molecular probes and labeled compounds for studying biological pathways and mechanisms.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce the oxazole moiety into more complex systems.
• Heterocyclic Library Synthesis: A critical building block for combinatorial and parallel synthesis to generate diverse libraries of oxazole derivatives for high-throughput screening.

Basic Information

Product Name	4-Iodo-Oxazole-5-Carboxylic Acid Ethyl Ester
CAS No.	220580-92-7
Molecular Formula	C6H6INO3
Molecular Weight	266.03 g/mol
Synonyms	Ethyl 4-Iodo-1,3-Oxazole-5-Carboxylate; 4-Iodooxazole-5-carboxylic Acid Ethyl Ester; 5-Carbethoxy-4-iodooxazole; 4-Iodo-5-ethoxycarbonyloxazole; 1,3-Oxazole-5-carboxylic acid, 4-iodo-, ethyl ester; Ethyl 4-iodooxazole-5-carboxylate; 4-Iodo-5-oxazolecarboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 4-Iodo-Oxazole-5-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.