Description

Methyl 3-(Bromomethyl)-4-Chlorobenzoate is a versatile and high-value organic building block, primarily utilized in advanced pharmaceutical synthesis and fine chemical manufacturing. Its molecular structure, featuring both bromomethyl and chlorobenzoate functional groups, makes it a critical intermediate for constructing complex molecules through cross-coupling and substitution reactions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity intermediates for their synthetic pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated benzoate scaffolds.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides where the chlorobenzoate moiety is a common structural feature.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis.
• Material Science Research: Employed in the creation of novel organic monomers and polymers for advanced materials.
• Cross-Coupling Reactions: The bromomethyl group is an effective handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleophilic Substitution: Reacts with various nucleophiles, enabling the introduction of diverse functional groups at the benzylic position.

Basic Information

Product Name	Methyl 3-(Bromomethyl)-4-Chlorobenzoate
CAS No.	220464-68-6
Molecular Formula	C9H8BrClO2
Molecular Weight	263.52 g/mol
Synonyms	4-Chloro-3-(bromomethyl)benzoic acid methyl ester; Methyl 4-chloro-3-(bromomethyl)benzoate; 3-Bromomethyl-4-chlorobenzoic acid methyl ester; Benzoic acid, 4-chloro-3-(bromomethyl)-, methyl ester; Methyl 3-bromomethyl-4-chlorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 3-(Bromomethyl)-4-Chlorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.