Description

Benzyl 4-Isocyanatotetrahydro-1(2H)-Pyridinecarboxylate is a versatile and reactive isocyanate derivative used as a key building block in advanced organic synthesis. This compound is crucial for introducing the protected piperidine-4-carboxylate moiety with a reactive isocyanate handle, enabling the construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Peptide Mimetic Synthesis: Used to incorporate constrained amino acid analogs and other pharmacophores into peptide chains to enhance stability and biological activity.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with improved efficacy.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the production of specialty polyurethanes and polymers with tailored properties.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes and molecular tools for studying enzyme function and biological pathways.
• Material Science: Employed in the surface functionalization of materials and the creation of advanced coatings and adhesives.

Basic Information

Product Name	Benzyl 4-Isocyanatotetrahydro-1(2H)-Pyridinecarboxylate
CAS No.	220394-91-2
Molecular Formula	C14H16N2O3
Molecular Weight	260.29 g/mol
Synonyms	Benzyl 4-Isocyanato-1,2,3,6-tetrahydropyridine-1-carboxylate; 1-(Benzyloxycarbonyl)-4-isocyanato-1,2,3,6-tetrahydropyridine; 4-Isocyanato-1-(phenylmethoxy)carbonyl-1,2,3,6-tetrahydropyridine; Cbz-4-isocyanato-1,2,3,6-tetrahydropyridine; N-Cbz-4-isocyanato-1,2,3,6-tetrahydropyridine; Benzyl N-(4-isocyanato-3,6-dihydro-2H-pyridin-1-yl)formate; 1,2,3,6-Tetrahydropyridine-1-carboxylic acid, 4-isocyanato-, benzyl ester
EINECS	Contact for details

Quality Control

Our Benzyl 4-Isocyanatotetrahydro-1(2H)-Pyridinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain reactivity.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.