Description

2H-Pyrazolo[4,3-C]Pyridine-2-Acetic Acid, 5-[(1,1-Dimethylethoxy)Carbonyl]-4,5,6,7-Tetrahydro-, Ethyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a versatile and sophisticated building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is essential for research institutions and pharmaceutical manufacturers engaged in developing new small-molecule drugs, where precise chemical structure and reliable purity are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially for central nervous system (CNS) and oncology targets.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex APIs that incorporate the pyrazolopyridine core structure.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of new chemical entities in academic and industrial R&D labs.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for cGMP-compliant production of clinical trial materials and commercial APIs.
• Biochemical Tool Compound: Potential use in developing biochemical probes for studying enzyme inhibition and cellular signaling pathways.

Basic Information

Product Name	2H-Pyrazolo[4,3-C]Pyridine-2-Acetic Acid, 5-[(1,1-Dimethylethoxy)Carbonyl]-4,5,6,7-Tetrahydro-, Ethyl Ester
CAS No.	220388-73-8
Molecular Formula	C17H24N2O4
Molecular Weight	320.39 g/mol
Synonyms	Ethyl 5-(tert-butoxycarbonyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-2-acetate; 5-(Boc)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-2-acetic acid ethyl ester; 2H-Pyrazolo[4,3-c]pyridine-2-acetic acid, 4,5,6,7-tetrahydro-5-[[(1,1-dimethylethoxy)carbonyl]]-, ethyl ester; tert-Butyl 2-(2-ethoxy-2-oxoethyl)-2,4,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5-carboxylate; Boc-protected ethyl pyrazolopyridine acetate; CAS 220388-73-8
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency suitable for pharmaceutical R&D and pre-clinical applications. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting purity, identity, and impurity profiles. We support our partners with full traceability and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.