Description

n-Acetyl-9-Azido-9-Deoxyneuraminic Acid Methyl Ester 2,4,7,8-Tetraacetate is a key synthetic intermediate and functionalized sialic acid derivative. This compound is crucial for bioorthogonal chemistry and glycobiology research, enabling the study and modification of cell surface glycans. It is primarily utilized by researchers and manufacturers in pharmaceutical development, diagnostic reagent production, and advanced chemical biology applications.

Application

• Bioorthogonal Labeling: The azido group enables selective conjugation via click chemistry (e.g., CuAAC, SPAAC) for labeling cell surface glycans.
• Glycoconjugate Synthesis: Serves as a critical building block for the chemical and enzymatic synthesis of azide-modified sialosides and complex oligosaccharides.
• Metabolic Glycoengineering: Used as a precursor for metabolic substrates to introduce chemical reporters into cellular glycans for imaging and profiling.
• Antiviral Research: Investigated as an intermediate in the development of sialidase inhibitors and antiviral agents targeting influenza and other viruses.
• Vaccine Development: Employed in the design and synthesis of carbohydrate-based antigens and conjugate vaccines.
• Diagnostic Probes: Utilized to create labeled probes for detecting sialic acid-binding proteins (lectins, antibodies) and pathogens.
• Drug Delivery Systems: Functionalized onto nanoparticles or polymers for targeted delivery applications.
• Biomaterial Functionalization: Used to introduce bio-recognition elements onto surfaces for biosensors and cell culture substrates.

Basic Information

Product Name	n-Acetyl-9-Azido-9-Deoxyneuraminic Acid Methyl Ester 2,4,7,8-Tetraacetate
CAS No.	219814-64-9
Molecular Formula	C22H30N4O13
Molecular Weight	558.50 g/mol
Synonyms	Methyl 5-acetamido-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-non-2-ulopyranosidonic acid 2,4,7,8-tetraacetate; 9-Azido-9-deoxy-N-acetylneuraminic acid methyl ester peracetate; 9-Azido-Neu5Ac Methyl Ester Peracetate; 9-Azido-Neu5Ac1Me 2,4,7,8-Tetra-O-acetate; Sialic Acid Azide Derivative; Azido Sialic Acid Methyl Ester Peracetate; Peracetylated 9-Azido Neu5Ac Methyl Ester
EINECS	Contact for details

Quality Control

Our n-Acetyl-9-Azido-9-Deoxyneuraminic Acid Methyl Ester 2,4,7,8-Tetraacetate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under inert atmosphere if specified and opened in a controlled, dry environment to minimize degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.