Description

(R)-Methyl 2-(Diphenylmethyleneamino)-3-Hydroxypropanoate CAS NO 218766-08-6 is a high-purity chiral intermediate of significant importance in asymmetric synthesis. Its core value lies in providing a stereochemically defined building block for the construction of complex molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the fine chemical and pharmaceutical industries who require reliable, high-quality intermediates for producing active pharmaceutical ingredients (APIs) and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure drugs, particularly β-amino alcohols and related therapeutic agents.
• Asymmetric Synthesis: Used as a precursor for chiral catalysts and ligands in stereoselective chemical transformations.
• Peptidomimetics Research: Serves as a building block for the development of peptide analogs and protease inhibitors.
• Agrochemical Development: Employed in the research and production of chiral pesticides and herbicides.
• Academic & R&D: A valuable reagent for universities and contract research organizations (CROs) exploring new synthetic methodologies.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value fine chemicals.

Basic Information

Product Name	(R)-Methyl 2-(Diphenylmethyleneamino)-3-Hydroxypropanoate
CAS No.	218766-08-6
Molecular Formula	C17H17NO3
Molecular Weight	283.32 g/mol
Synonyms	(R)-Methyl 2-[(Diphenylmethylene)amino]-3-hydroxypropanoate; Methyl (2R)-2-[(Diphenylmethylidene)amino]-3-hydroxypropanoate; (R)-Methyl 2-(Benzoin imino)-3-hydroxypropionate; (R)-2-(Diphenylmethyleneamino)-3-hydroxypropionic acid methyl ester; (R)-Methyl 3-hydroxy-2-(diphenylmethyleneamino)propanoate; (R)-Methyl 2-(Diphenylmethylideneamino)-3-hydroxypropanoate; (R)-Methyl 2-(N-(Diphenylmethylene)amino)-3-hydroxypropionate
EINECS	Contact for details

Quality Control

Our (R)-Methyl 2-(Diphenylmethyleneamino)-3-Hydroxypropanoate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Production adheres to current industry standards, and each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles. We support compliance with cGMP and ISO guidelines for pharmaceutical intermediates, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.