Description

1-(4-Methoxyphenyl)-5-Methyl-3-(Trifluoromethyl)-1H-Pyrazole is a high-purity, advanced pharmaceutical intermediate characterized by its distinct pyrazole core substituted with methoxyphenyl and trifluoromethyl groups. This compound matters for its critical role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting inflammation and central nervous system disorders. Pharmaceutical R&D teams and fine chemical manufacturers need this precise intermediate to develop next-generation therapeutics with improved efficacy and metabolic profiles.

Application

• Pharmaceutical Intermediate: Serves as a core scaffold for the development of non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors.
• Agrochemical Synthesis: Used in research for creating novel pesticides and herbicides, leveraging the biological activity of the pyrazole moiety.
• Material Science Research: Investigated as a precursor for specialty polymers and liquid crystals due to its aromatic and fluorinated structure.
• Organic Synthesis Building Block: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Biochemical Research: Utilized as a reference standard or probe in enzymatic and receptor binding assays.

Basic Information

Product Name	1-(4-Methoxyphenyl)-5-Methyl-3-(Trifluoromethyl)-1H-Pyrazole
CAS No.	218632-10-1
Molecular Formula	C12H11F3N2O
Molecular Weight	256.23 g/mol
Synonyms	5-Methyl-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole; 1-(4-Methoxyphenyl)-5-methyl-3-(trifluoromethyl)pyrazole; 3-Trifluoromethyl-5-methyl-1-(4-methoxyphenyl)pyrazole; 1H-Pyrazole, 1-(4-methoxyphenyl)-5-methyl-3-(trifluoromethyl)-; 218632-10-1; 5-Methyl-3-trifluoromethyl-1-(4-methoxyphenyl)pyrazole
EINECS	Contact for details

Quality Control

Our 1-(4-Methoxyphenyl)-5-Methyl-3-(Trifluoromethyl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.