Description

(-)-Methyl (3S)-3,5-Bis-[(tert-Butyldimethylsilyl)Oxy]-2,2-Dimethylpentanoate is a high-purity, chiral synthetic intermediate featuring dual tert-butyldimethylsilyl (TBS) protecting groups. This compound matters for its critical role in the stereoselective synthesis of complex bioactive molecules, offering precise control over molecular architecture. It is primarily needed by research and development laboratories and production facilities in the pharmaceutical and fine chemical industries engaged in the synthesis of advanced drug candidates and natural products.

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting metabolic and infectious diseases.
• Asymmetric Synthesis: Utilized in stereocontrolled reactions to construct molecules with defined three-dimensional configurations, essential for drug efficacy and safety.
• Natural Product Synthesis: Serves as a precursor in the total synthesis of complex natural products with potential therapeutic benefits.
• Process Chemistry & Scale-Up: Employed in route development and optimization for the commercial-scale manufacturing of chiral compounds.
• Academic & Industrial R&D: Used in exploratory chemistry for developing novel synthetic methodologies and discovering new chemical entities.
• Protecting Group Chemistry: Demonstrates the application of robust silyl ether protecting groups for selective functional group manipulation in complex molecular settings.

Basic Information

Product Name	(-)-Methyl (3S)-3,5-Bis-[(tert-Butyldimethylsilyl)Oxy]-2,2-Dimethylpentanoate
CAS No.	218614-13-2
Molecular Formula	C20H44O4Si2
Molecular Weight	404.74 g/mol
Synonyms	Methyl (3S)-3,5-bis[(tert-butyldimethylsilyl)oxy]-2,2-dimethylpentanoate; (3S)-3,5-Bis[(tert-butyldimethylsilyl)oxy]-2,2-dimethylpentanoic Acid Methyl Ester; (-)-Methyl 3,5-Bis-O-(tert-butyldimethylsilyl)-2,2-dimethylpentanoate; (S)-Methyl 3,5-bis((tert-butyldimethylsilyl)oxy)-2,2-dimethylpentanoate; TBS-protected methyl pentanoate derivative; CAS 218614-13-2.
EINECS	Contact for details

Quality Control

Our (-)-Methyl (3S)-3,5-Bis-[(tert-Butyldimethylsilyl)Oxy]-2,2-Dimethylpentanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and specific test results are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened for use to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.