Description

(3S)-4-([tert-Butyl(Dimethyl)Silyl]Oxy)-3-Methylbutyl Phenyl Sulfone is a high-purity, chiral organosilicon intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex, stereochemically defined molecules, particularly in the pharmaceutical sector. It is primarily needed by research chemists and process development scientists in the fine chemical and pharmaceutical industries for the synthesis of active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel drug candidates, especially those requiring specific stereochemistry.
• Asymmetric Synthesis: Utilized as a building block in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Process Chemistry: Serves in the research, development, and scale-up of efficient synthetic routes for target molecules in pilot plants and commercial manufacturing.
• Medicinal Chemistry Research: Used in the discovery phase for structure-activity relationship (SAR) studies and the preparation of analog libraries.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) group can act as a protective group for alcohols in complex synthetic sequences.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, agrochemical intermediates, and advanced materials requiring precise structural control.

Basic Information

Product Name	(3S)-4-([tert-Butyl(Dimethyl)Silyl]Oxy)-3-Methylbutyl Phenyl Sulfone
CAS No.	218613-98-0
Molecular Formula	C17H30O3SSi
Molecular Weight	342.57 g/mol
Synonyms	(3S)-4-[(tert-Butyldimethylsilyl)oxy]-3-methylbutyl phenyl sulfone; (S)-4-((tert-Butyldimethylsilyl)oxy)-3-methylbutyl phenyl sulfone; 1-[(4-Methylpentyl)oxy]-4-(phenylsulfonyl)butane (stereoisomer); TBDMS-protected chiral sulfone intermediate; (3S)-4-(tert-Butyldimethylsiloxy)-3-methylbutyl phenyl sulfone; Phenyl [(3S)-4-[(1,1-dimethylethyl)dimethylsilyl]oxy-3-methylbutyl] sulfone
EINECS	Contact for details

Quality Control

Our (3S)-4-([tert-Butyl(Dimethyl)Silyl]Oxy)-3-Methylbutyl Phenyl Sulfone is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity, chemical purity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, containers should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.