Description

Proline, 4-Hydroxy-, Methyl Ester (9Ci) CAS NO 217184-95-7 is a high-purity, protected amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise stereochemistry and functional group compatibility in complex molecule construction. It is primarily utilized by the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of peptidomimetics, protease inhibitors, and other bioactive molecules.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and plant growth regulators with specific stereochemical requirements.
• Peptide Chemistry: Serves as a protected hydroxyproline derivative for solid-phase and solution-phase peptide synthesis (SPPS).
• Chemical Biology: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical studies.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in catalytic asymmetric transformations.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances where high enantiopurity is mandated.

Basic Information

Product Name	Proline, 4-Hydroxy-, Methyl Ester (9Ci)
CAS No.	217184-95-7
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	Methyl 4-hydroxyprolinate; 4-Hydroxy-L-proline methyl ester; L-4-Hydroxyproline methyl ester; (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester; trans-4-Hydroxy-L-proline methyl ester; Methyl (4R)-4-hydroxy-L-prolinate; Methyl trans-4-hydroxy-L-prolinate; 4-Hydroxyproline methyl ester hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our Proline, 4-Hydroxy-, Methyl Ester (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.