Description

N3-Peg5-Ch2Cooh is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group at one terminus and a carboxylic acid at the other. This compound is essential for creating stable, biocompatible conjugates in advanced bioconjugation and materials science applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic industries for developing antibody-drug conjugates (ADCs), peptide modifications, and functionalized nanoparticles.

Application

• Bioconjugation and ADC Development: Serves as a critical linker for connecting cytotoxic drugs to monoclonal antibodies via click chemistry and carbodiimide coupling.
• PEGylation of Peptides and Proteins: Used to modify therapeutic biomolecules to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Surface Functionalization: Enables the attachment of biomolecules to nanoparticles, quantum dots, and other material surfaces for targeted drug delivery and biosensing.
• Polymer Chemistry: Acts as a building block for synthesizing functionalized hydrogels, dendrimers, and other advanced polymeric materials.
• Diagnostic Reagent Synthesis: Facilitates the development of fluorescent probes and assay components through its reactive end groups.
• Crosslinking Agent: Used to create covalent networks between molecules containing complementary functional groups like amines and alkynes.

Basic Information

Product Name	N3-Peg5-Ch2Cooh
CAS No.	217180-81-9
Molecular Formula	C19H35N3O9
Molecular Weight	449.5 g/mol
Synonyms	Azido-PEG5-acid; 15-Azido-4,7,10,13-tetraoxapentadecanoic acid; N3-PEG5-COOH; Azido-Pentaethylene glycol-acetic acid; 2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; PEG5-Azide-Acid; Heterobifunctional PEG linker, N3-PEG5-COOH
EINECS	Contact for details

Quality Control

Every batch of N3-Peg5-Ch2Cooh is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure high purity and consistency. Our standard quality commitment includes comprehensive analysis by NMR, HPLC, and MS to verify structure, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature in a dry environment before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.