Description

7-Chloro-5-(4-Hydroxyphenyl)-1-Methyl-3-(2-Naphthylmethyl)-2,3-Dihydro-1H-1,4-Benzodiazepin-2-One is a high-purity, advanced pharmaceutical intermediate belonging to the 1,4-benzodiazepine class of compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel therapeutic agents targeting the central nervous system. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new drug candidates and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical precursor in the research and synthesis of novel benzodiazepine-derived drug candidates.
• Neurological Research: Used in the development of compounds for studying and targeting neurological receptors and pathways.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the multi-step synthesis of complex active pharmaceutical ingredients (APIs) for preclinical and clinical studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development.

Basic Information

Product Name	7-Chloro-5-(4-Hydroxyphenyl)-1-Methyl-3-(2-Naphthylmethyl)-2,3-Dihydro-1H-1,4-Benzodiazepin-2-One
CAS No.	216691-95-1
Molecular Formula	C27H21ClN2O2
Molecular Weight	440.92 g/mol
Synonyms	7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(naphthalen-2-ylmethyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 1,4-Benzodiazepin-2-one, 7-chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-; 216691-95-1; 3-(2-Naphthylmethyl)-7-chloro-5-(4-hydroxyphenyl)-1-methyl-1,4-benzodiazepin-2-one; 7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthalenylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one
EINECS	Contact for details

Quality Control

Our 7-Chloro-5-(4-Hydroxyphenyl)-1-Methyl-3-(2-Naphthylmethyl)-2,3-Dihydro-1H-1,4-Benzodiazepin-2-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.