Description

Methyl 3,5-Difluorobenzoate is a high-purity fluorinated aromatic ester, a crucial building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the benzoate ring, which significantly influences the electronic and steric properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, serving as a key intermediate for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A vital precursor in synthesizing active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorophenyl moiety to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the production of modern herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in displays and lighting.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, or specific surface properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Organic Synthesis Reagent: Employed in laboratories for introducing the 3,5-difluorobenzoate group into more complex molecular architectures.

Basic Information

Product Name	Methyl 3,5-Difluorobenzoate
CAS No.	216393-55-4
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	3,5-Difluorobenzoic Acid Methyl Ester; Methyl 3,5-Difluorobenzoate; Benzoic acid, 3,5-difluoro-, methyl ester; Methyl 3,5-Difluorobenzenecarboxylate; 3,5-Difluorophenylcarboxylic Acid Methyl Ester; MFCD03094045; Methyl m,p-Difluorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 3,5-Difluorobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring reliable and traceable raw materials for GMP or research purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.