Description

4,5-Diiodo-1-(2-Trimethylsilanyl-Ethoxymethyl)-1H-Imidazole is a specialized organosilicon-protected imidazole derivative, serving as a critical synthetic intermediate in advanced organic and medicinal chemistry. Its core value lies in the strategic protection of the reactive imidazole nitrogen, enabling precise functionalization and controlled reactivity in multi-step synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for developing novel active ingredients and complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially nucleoside analogs and antiviral/antitumor agents.
• Agrochemical Synthesis: Used in the development of advanced fungicides and herbicides that require specific heterocyclic scaffolds.
• Material Science Precursor: Serves as a monomer or functionalizing agent for creating specialty polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: The diiodo functionality makes it a valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex molecular architectures.
• Ligand and Catalyst Development: Used to synthesize novel N-heterocyclic carbene (NHC) precursors and other specialized ligands for catalysis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and enzyme mechanisms.

Basic Information

Product Name	4,5-Diiodo-1-(2-Trimethylsilanyl-Ethoxymethyl)-1H-Imidazole
CAS No.	216314-79-3
Molecular Formula	C9H16I2N2OSi
Molecular Weight	466.13 g/mol
Synonyms	1-[(2-Trimethylsilyl)ethoxymethyl]-4,5-diiodo-1H-imidazole; 4,5-Diiodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole; 4,5-Diiodo-1-SEM-imidazole; 1H-Imidazole, 4,5-diiodo-1-[(2-(trimethylsilyl)ethoxy)methyl]-; SEM-protected 4,5-diiodoimidazole; 216314-79-3; 4,5-Diiodo-1-SEM-Imidazole
EINECS	Contact for details

Quality Control

Our 4,5-Diiodo-1-(2-Trimethylsilanyl-Ethoxymethyl)-1H-Imidazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and elemental analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Specifications can be tailored to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.