Description

5-((Trimethylsilyl)Ethynyl)Pyrimidine is a high-purity organosilicon building block featuring a reactive ethynylpyrimidine core protected by a trimethylsilyl (TMS) group. This compound is critical for advanced organic synthesis, particularly in cross-coupling reactions like the Sonogashira reaction, where it serves as a key intermediate for constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug candidates, particularly those requiring pyrimidine-based heterocycles for targeted therapies.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the pyrimidine moiety is a common pharmacophore.
• Material Science: Serves as a precursor for creating advanced polymers, liquid crystals, and organic electronic materials through controlled polymerization or functionalization.
• Cross-Coupling Reactions: Acts as a protected acetylene source in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for biochemical and diagnostic research.
• Organic Synthesis: A versatile reagent for introducing the ethynylpyrimidine functionality into larger, more complex organic molecules under mild conditions.

Basic Information

Item	Details
Product Name	5-((Trimethylsilyl)Ethynyl)Pyrimidine
CAS No.	216309-28-3
Molecular Formula	C9H14N2Si
Molecular Weight	178.31 g/mol
Synonyms	5-[(Trimethylsilyl)ethynyl]pyrimidine; 5-(2-Trimethylsilylethynyl)pyrimidine; Pyrimidine, 5-[(trimethylsilyl)ethynyl]-; 5-Ethynyl-2-(trimethylsilyl)pyrimidine; TMS-Ethynylpyrimidine; (5-Pyrimidinyl)(trimethylsilyl)acetylene
EINECS	Contact for details

Quality Control

Our 5-((Trimethylsilyl)Ethynyl)Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports applications in cGMP environments and research requiring the highest material integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and reactivity. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.