Description

Fmoc-4-Diethylphosphomethyl-D-Phenylalanine is a specialized, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is critical for introducing a phosphonate moiety, a key functional group for creating phosphate mimetics and modulating peptide bioactivity. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing novel therapeutic peptides, enzyme inhibitors, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected building block for the automated synthesis of phosphonopeptides.
• Phosphate Mimetic Development: Incorporation into peptides to create stable analogs of phosphoserine, phosphothreonine, or phosphotyrosine for drug discovery.
• Enzyme Inhibitor Design: Synthesis of potent and selective inhibitors for phosphatases, kinases, and other phosphoryl-transfer enzymes.
• Chemical Biology Probes: Construction of activity-based probes and tools for studying protein phosphorylation and signal transduction pathways.
• Material Science: Potential use in creating functionalized surfaces or polymers with specific metal-chelating properties.

Basic Information

Product Name	Fmoc-4-Diethylphosphomethyl-D-Phenylalanine
CAS No.	215600-05-8
Molecular Formula	C27H36NO6P
Molecular Weight	525.55 g/mol
Synonyms	Fmoc-Phe(4-PO(OEt)2)-OH; Fmoc-D-Phe(4-diethylphosphonomethyl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-(diethylphosphonomethyl)-D-phenylalanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((diethoxyphosphoryl)methyl)phenyl)propanoic acid; Fmoc-4-(Diethylphosphonomethyl)-D-phenylalanine; Fmoc-D-4-(Diethylphosphonomethyl)Phenylalanine; Fmoc-Phosphonomethyl-D-Phenylalanine derivative
EINECS	Contact for details

Quality Control

Our Fmoc-4-Diethylphosphomethyl-D-Phenylalanine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.