Description

2-[2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethoxy]ethanamine is a specialized organosilicon-protected amine derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its dual functionality, where the silyl ether group provides robust protection for hydroxyl moieties, while the primary amine offers a versatile handle for further chemical elaboration. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the multi-step synthesis of complex molecules like active pharmaceutical ingredients (APIs), peptides, and novel materials where selective protection and deprotection strategies are paramount.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs), especially where orthogonal protecting group strategies are required.
• Peptide Synthesis: Used as a protected linker or spacer in solid-phase and solution-phase peptide synthesis to introduce functionalized ethylene glycol chains.
• Polymer & Material Science: Serves as a functional monomer or chain extender for creating specialty polymers, dendrimers, and silicon-containing hybrid materials with tailored properties.
• Ligand & Catalyst Development: Employed in the preparation of chelating ligands and organocatalysts, where the amine and ether functionalities can coordinate to metal centers or act as hydrogen bond donors/acceptors.
• Surface Modification: Utilized to functionalize silica, glass, or other oxide surfaces via silane chemistry, introducing amine-terminated polyethylene glycol (PEG)-like chains for biocompatibility or further conjugation.
• Bioconjugation Chemistry: Acts as a heterobifunctional crosslinker for attaching biomolecules (proteins, oligonucleotides) to particles, surfaces, or other molecules.

Basic Information

Item	Details
Product Name	2-[2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethoxy]ethanamine
CAS No.	215297-17-9
Molecular Formula	C10H25NO2Si
Molecular Weight	219.40 g/mol
Synonyms	2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethanamine; N-[2-[2-[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethoxy]ethyl]amine; TBDMS-protected amino-PEG2; Amino-PEG2-TBDMS; 2,5,8-Trioxa-11-aza-1-silaundecane, 1,1-dimethyl-1-(1,1-dimethylethyl)-; tert-Butyl[2-(2-aminoethoxy)ethoxy]dimethylsilane; (2-(2-Aminoethoxy)ethoxy)(tert-butyl)dimethylsilane
EINECS	Contact for details

Quality Control

Our 2-[2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]ethoxy]ethanamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to consistent quality and supply chain reliability makes us a trusted partner for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.