Description

2-(n-T-Butoxycarbonylamino)Ethylisocyanide is a specialized isocyanide building block used in multi-component reactions for the synthesis of complex heterocycles and peptidomimetics. This compound is critical for medicinal chemistry and drug discovery research, enabling the rapid assembly of diverse chemical libraries. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical researchers, and academic institutions focused on organic synthesis and chemical biology.

Application

• Medicinal Chemistry: A key reagent in Ugi and Passerini multi-component reactions for the efficient synthesis of novel drug-like scaffolds and compound libraries.
• Peptidomimetic Synthesis: Used to incorporate isocyanide functionality into peptide backbones, creating stable analogs for biological evaluation.
• Heterocycle Construction: Facilitates the one-pot synthesis of complex heterocyclic structures, including oxazoles and imidazoles, which are common pharmacophores.
• Chemical Biology Probes: Enables the labeling and modification of biomolecules for studying protein-protein interactions and cellular pathways.
• Agrochemical Research: Employed in the discovery and development of new active ingredients with novel modes of action.
• Academic Research & Development: Serves as a versatile building block in methodological studies and the discovery of new synthetic transformations.

Basic Information

Product Name	2-(n-T-Butoxycarbonylamino)Ethylisocyanide
CAS No.	215254-91-4
Molecular Formula	C8H14N2O2
Molecular Weight	170.21 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]ethyl isocyanide; 2-(Boc-amino)ethyl isocyanide; N-Boc-2-aminoethyl isocyanide; 2-Isocyanoethyl carbamic acid tert-butyl ester; tert-Butyl N-(2-isocyanoethyl)carbamate; Boc-NH-CH2-CH2-NC; 2-(tert-Butoxycarbonylamino)ethyl isonitrile
EINECS	Contact for details

Quality Control

Our 2-(n-T-Butoxycarbonylamino)Ethylisocyanide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is analyzed via HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a dry, well-ventilated area. This material is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.