Description

α-Methyl Omuralide CAS NO 215232-00-1 is a specialized synthetic intermediate of significant interest in advanced organic synthesis and pharmaceutical research. This compound is valued for its unique structural framework, which serves as a key building block in the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of complex natural product analogs and proteasome inhibitors.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel proteasome inhibitors and other targeted therapeutic agents.
• Organic Synthesis Building Block: Used in advanced multi-step synthetic routes for constructing complex molecular architectures, particularly lactone-based structures.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Biochemical Tool Compound: Employed in biochemical assays to study proteasome function and cellular protein degradation pathways.
• Academic Research: Utilized in university and institutional labs for methodological development in synthetic organic chemistry.

Basic Information

Product Name	α-Methyl Omuralide
CAS No.	215232-00-1
Molecular Formula	C16H21NO5
Molecular Weight	307.34 g/mol
Synonyms	(2S,3R,4S,5R,6S)-3,4-Dihydroxy-5-methoxy-2,6-dimethyl-9-oxo-1,7-dioxaspiro[4.4]non-8-ene; NPI-0052 analog; Salinosporamide A derivative; Lactacystin analog; Omuralide methyl derivative; Proteasome inhibitor intermediate; Spiro-β-lactone-γ-lactam
EINECS	Contact for details

Quality Control

Our α-Methyl Omuralide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.