Description

Carbamic Acid, [(2S)-2-Hydroxy-3-Methylbutyl]-, 1,1-Dimethylethyl Ester (9Ci) is a chiral, optically active carbamate derivative that serves as a critical protected intermediate in advanced organic synthesis. Its value lies in providing a robust tert-butoxycarbonyl (Boc) protecting group for amines, coupled with a stereodefined hydroxyalkyl side chain, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors developing novel active ingredients, particularly where stereochemical integrity is paramount. The CAS number for this compound is 214679-15-9.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of chiral drug candidates, especially protease inhibitors and other small molecule therapeutics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce Boc-protected amino acid analogs with additional functional handles.
• Agrochemical Synthesis: Intermediate in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Chiral Auxiliary/ Ligand Precursor: The defined stereocenter makes it a valuable starting material for synthesizing chiral ligands used in asymmetric catalysis.
• Chemical Biology Probes: Employed in the development of activity-based probes and other tools for studying enzymatic processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for use in bespoke, multi-step synthetic routes for client projects.

Basic Information

Product Name	Carbamic Acid, [(2S)-2-Hydroxy-3-Methylbutyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	214679-15-9
Molecular Formula	C11H23NO3
Molecular Weight	217.31 g/mol
Synonyms	(2S)-2-Hydroxy-3-methylbutyl carbamic acid tert-butyl ester; tert-Butyl N-[(2S)-2-hydroxy-3-methylbutyl]carbamate; (S)-2-Hydroxy-3-methylbutylcarbamic acid tert-butyl ester; Boc-L-valinol (common name); N-Boc-L-valinol; N-(tert-Butoxycarbonyl)-L-valinol; (2S)-1-[(tert-Butoxycarbonyl)amino]-3-methylbutan-2-ol; L-Valinol, N-Boc-protected
EINECS	Contact for details

Quality Control

Our Carbamic Acid, [(2S)-2-Hydroxy-3-Methylbutyl]-, 1,1-Dimethylethyl Ester (9Ci) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC to ensure enantiomeric purity and standard pharmacopeial identification tests. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to guarantee compliance with your research or cGMP intermediate specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.