Description

8-Iodo-1,4-Dioxaspiro[4.5]Decane is a valuable spirocyclic iodinated building block in advanced organic synthesis. This compound is crucial for the efficient construction of complex molecular architectures, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for introducing iodine functional groups and spirocyclic motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators requiring spirocyclic structures.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Employed in the research of advanced organic electronic materials and liquid crystals.
• Cross-Coupling Reactions: Acts as a reliable electrophilic partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form carbon-carbon bonds.
• Radical Chemistry: Utilized as an iodine radical source or precursor in various radical-mediated synthetic transformations.

Basic Information

Product Name	8-Iodo-1,4-Dioxaspiro[4.5]Decane
CAS No.	213833-68-2
Molecular Formula	C8H13IO2
Molecular Weight	268.09 g/mol
Synonyms	8-Iodo-1,4-dioxaspiro[4.5]decane; 1,4-Dioxaspiro[4.5]decane, 8-iodo-; 8-Iodospiro[1,3-dioxolane-2,1'-cyclohexane]; Iodospiroketal; 8-Iodo-1,4-dioxaspiro(4.5)decane; Spiro[1,3-dioxolane-2,1'-cyclohexane], 4'-iodo-
EINECS	Contact for details

Quality Control

Our 8-Iodo-1,4-Dioxaspiro[4.5]Decane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.