Description

Spiro[2.2]Pentanepropanoic Acid, α-Amino-2-Methylene- (9Ci) is a specialized, high-value spirocyclic amino acid derivative used as a critical building block in advanced organic synthesis. Its unique constrained spiro[2.2]pentane scaffold and functional groups make it an essential intermediate for constructing complex molecular architectures with precise stereochemistry. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the creation of novel herbicides and pesticides, where its rigid structure can impart favorable biological activity and environmental stability.
• Ligand and Catalyst Development: Employed in the design of novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Peptidomimetics and Bioisosteres: The spiro[2.2]pentane moiety is a valuable bioisostere for cyclopropyl or other aliphatic rings in medicinal chemistry programs, improving metabolic stability and binding affinity.
• Material Science Research: Investigated as a monomer or additive for creating polymers with unique thermal and mechanical properties due to its highly strained ring system.
• Academic and R&D Laboratories: A valuable reagent for methodological studies in organic chemistry, exploring new ring-forming reactions and synthetic transformations.

Basic Information

Product Name	Spiro[2.2]Pentanepropanoic Acid, α-Amino-2-Methylene- (9Ci)
CAS No.	213198-59-5
Molecular Formula	C9H13NO2
Molecular Weight	167.21 g/mol
Synonyms	2-Methylene-1-aminospiro[2.2]pentane-1-propanoic acid; 3-(2-Methylenespiro[2.2]pentan-1-ylamino)propanoic acid; 1-Amino-2-methylenespiro[2.2]pentane-1-propanoic acid; α-Amino-2-methylenespiro[2.2]pentanepropanoic acid; Spiro[2.2]pentane-1-propanoic acid, α-amino-2-methylene-; (1-Amino-2-methylenespiro[2.2]pentan-1-yl)propanoic acid
EINECS	Contact for details

Quality Control

Our Spiro[2.2]Pentanepropanoic Acid, α-Amino-2-Methylene- (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive synthetic applications. We provide comprehensive analytical data including HPLC purity, chiral purity (where applicable), and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is supplied with each batch, and custom synthesis to meet specific purity or enantiomeric excess requirements is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Standard Grade)
Chiral Purity (Chiral HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.