Description

Boc-D-Nva-Osu is a high-purity, activated ester derivative of the non-proteinogenic amino acid D-Norvaline, protected at the N-terminus with a tert-butyloxycarbonyl (Boc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient and racemization-free incorporation of D-Norvaline into complex peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and biochemical probes where precise stereochemistry and side-chain functionality are required.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key reagent for the controlled, stepwise elongation of peptide chains, particularly for introducing the D-isomer of Norvaline.
• Pharmaceutical R&D: Synthesis of peptide-based drug candidates, hormone analogs, and antimicrobial peptides with enhanced metabolic stability.
• Bioconjugation: Facile coupling agent for attaching peptide motifs to other molecules, surfaces, or carriers in bioconjugate chemistry.
• Chemical Biology: Building block for creating custom peptide libraries, enzyme substrates, and inhibitors for proteomic studies.
• Material Science: Incorporation into bio-inspired polymers and smart materials that require specific amino acid sequences.

Basic Information

Product Name	Boc-D-Nva-Osu
CAS No.	213178-93-9
Molecular Formula	C₁₄H₂₄N₂O₆
Molecular Weight	316.35 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-norvaline N-hydroxysuccinimide ester; Boc-D-Norvaline-OSu; N-Boc-D-Norvaline succinimidyl ester; Nα-Boc-D-Norvaline N-succinimidyl ester; (R)-2-((tert-Butoxycarbonyl)amino)pentanoic acid 2,5-dioxopyrrolidin-1-yl ester; D-Boc-Norvaline-OSu; Boc-D-2-Aminopentanoic acid N-succinimidyl ester; Boc-D-Nva-OSU
EINECS	Contact for details

Quality Control

Our Boc-D-Nva-Osu is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes to support your research and development activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.