Description

(3,4-Dimethoxy-Phenyl)-Phosphonic Acid Diethyl Ester is a high-purity organophosphorus compound that serves as a versatile and critical synthetic intermediate. Its value lies in its functionalized aromatic ring and phosphonate ester group, enabling its use in the construction of complex molecules for advanced applications. This product is essential for R&D chemists and process development teams in the pharmaceutical and agrochemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting the central nervous system or requiring specific phosphonate bioisosteres.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where the dimethoxyphenyl moiety imparts specific biological activity.
• Ligand and Catalyst Precursor: Serves as a starting material for the preparation of specialized phosphine-based ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs or charge-transport layers, due to its electron-donating methoxy groups.
• Chemical Biology Probes: Useful for synthesizing activity-based probes or inhibitors that target enzymes interacting with phosphonate esters.
• Scale-up and Process Chemistry: Supplied in development and commercial quantities to support process optimization and manufacturing campaigns.

Basic Information

Product Name	(3,4-Dimethoxy-Phenyl)-Phosphonic Acid Diethyl Ester
CAS No.	213032-75-8
Molecular Formula	C12H19O5P
Molecular Weight	274.25 g/mol
Synonyms	Diethyl (3,4-Dimethoxyphenyl)phosphonate; (3,4-Dimethoxyphenyl)phosphonic Acid Diethyl Ester; Diethyl 3,4-Dimethoxybenzene-1-phosphonate; Phosphonic Acid, P-(3,4-Dimethoxyphenyl)-, Diethyl Ester; Diethyl (3,4-Dimethoxybenzyl)phosphonate (common misnomer); 213032-75-8; 3,4-Dimethoxyphenylphosphonic Acid Diethyl Ester
EINECS	Contact for details

Quality Control

Our (3,4-Dimethoxy-Phenyl)-Phosphonic Acid Diethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.