Description

tert-Butyl (2R)-2-Amino-4-Oxo-2-Phenylbutanoate is a high-purity chiral amino acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, enantiomerically pure scaffold essential for constructing complex molecules with defined stereochemistry. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs), peptide mimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, enzyme inhibitors, and other targeted therapeutics.
• Peptidomimetics Research: Used in the design and construction of non-peptide compounds that mimic peptide structure and function.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to introduce chirality.
• API Development: A crucial building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Bioconjugation & Labeling: The reactive amino and carbonyl groups facilitate conjugation with other molecules for diagnostic or drug delivery applications.
• Academic & Industrial R&D: Serves as a valuable reagent in medicinal chemistry and organic synthesis research programs.

Basic Information

Product Name	tert-Butyl (2R)-2-Amino-4-Oxo-2-Phenylbutanoate
CAS No.	212560-65-1
Molecular Formula	C₁₄H₁₉NO₃
Molecular Weight	249.31 g/mol
Synonyms	(2R)-2-Amino-4-oxo-2-phenylbutanoic acid tert-butyl ester; (R)-tert-Butyl 2-amino-4-oxo-2-phenylbutanoate; (R)-2-Amino-4-oxo-2-phenylbutyric acid tert-butyl ester; tert-Butyl (R)-2-amino-4-oxo-2-phenylbutanoate; (R)-2-Amino-4-oxo-2-phenylbutanoic acid tert-butyl ester; (R)-Boc-Aminophenylpyruvic acid tert-butyl ester (common name variant); (2R)-2-Amino-4-oxo-2-phenyl-butyric acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (2R)-2-Amino-4-Oxo-2-Phenylbutanoate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.