Description

Gemcabene is a high-purity, small-molecule pharmaceutical intermediate with significant research and development interest. This compound is valued for its role as a key building block in the synthesis of novel therapeutic agents, particularly in the metabolic and cardiovascular disease space. It is primarily sought by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and fine chemical suppliers serving the global life sciences industry.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting dyslipidemia and related metabolic disorders.
• Research & Development: Used in medicinal chemistry programs for lead optimization and the development of new chemical entities (NCEs).
• Reference Standard: Employed as an analytical standard in quality control (QC) and method development for API and finished drug product analysis.
• Process Chemistry: Utilized in route scouting, scale-up studies, and process optimization within pilot plants and commercial manufacturing.
• Biochemical Research: Applied in in-vitro and in-vivo studies to investigate mechanisms of action related to lipid metabolism.
• Contract Synthesis: Supplied to CROs and CMOs for custom synthesis projects and clinical trial material (CTM) manufacturing.

Basic Information

Product Name	Gemcabene
CAS No.	209789-08-2
Molecular Formula	C17H14O4
Molecular Weight	282.29 g/mol
Synonyms	1,2-Bis(4-methoxyphenyl)-1,2-ethanedione; 4,4'-Dimethoxybenzil; NSC 758707; Gemcabene (USAN); CC-1; Benzil, 4,4'-dimethoxy-; Bis(4-methoxyphenyl)ethanedione
EINECS	Contact for details

Quality Control

Our Gemcabene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates, and specifications can be aligned with client-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.