Description

Benzyl 5-Fluorospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic molecular architecture. This compound is of significant commercial importance as a key building block in the synthesis of novel therapeutic agents, particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of innovative drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent bioactive molecules and active pharmaceutical ingredients (APIs).
• Drug Discovery & Medicinal Chemistry: Serves as a versatile scaffold for constructing compound libraries and exploring structure-activity relationships (SAR) in lead optimization programs.
• Neurological & Psychiatric Drug Research: Used in the development of potential therapeutics targeting receptors and enzymes within the CNS.
• Oncology Research: Employed as a building block for novel small-molecule inhibitors and targeted cancer therapies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-scale production of clinical trial materials.
• Academic & Institutional Research: Utilized in university and government laboratories for fundamental chemical and pharmacological studies.

Basic Information

Item	Details
Product Name	Benzyl 5-Fluorospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate
CAS No.	209348-85-6
Molecular Formula	C21H21FN2O2
Molecular Weight	352.41 g/mol
Synonyms	1'-Benzyloxycarbonyl-5-fluorospiro[indoline-3,4'-piperidine]; 5-Fluoro-1'-(phenylmethoxy)carbonylspiro[indole-3,4'-piperidine]; Benzyl 5-fluoro-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 5-Fluorospiro[indoline-3,4'-piperidine]-1'-carboxylic acid benzyl ester; Cbz-5-Fluorospiro[Indoline-3,4'-Piperidine]; Z-5-Fluorospiro[Indoline-3,4'-Piperidine]; 209348-85-6
EINECS	Contact for details

Quality Control

Every batch of Benzyl 5-Fluorospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high standards required for pharmaceutical research and development. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our commitment to consistent quality and traceability supports your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.