Description

5-Amino-3-Bromo-2-Fluoropyridine is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring amino, bromo, and fluoro substituents, makes it an exceptionally versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research institutions and industrial R&D teams in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl and conjugated systems.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new synthetic methodologies and creating novel chemical entities for screening libraries.
• Derivatization for Functional Materials: The amino group allows for further functionalization, enabling the creation of dyes, ligands for catalysis, and molecular sensors.

Basic Information

Product Name	5-Amino-3-Bromo-2-Fluoropyridine
CAS No.	209328-99-4
Molecular Formula	C5H4BrFN2
Molecular Weight	191.00 g/mol
Synonyms	3-Bromo-2-fluoro-5-aminopyridine; 2-Fluoro-5-amino-3-bromopyridine; 5-Amino-3-bromo-2-fluoropyridine; 3-Bromo-2-fluoro-5-pyridinamine; 2-Fluoro-3-bromo-5-pyridinamine; 5-Pyridinamine, 3-bromo-2-fluoro-; 209328-99-4
EINECS	Contact for details

Quality Control

Our 5-Amino-3-Bromo-2-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and cGMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.