Description

3-Chloro-2-Fluoro-5-Hydroxypyridine is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in cross-coupling and other metal-mediated reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing halogen groups.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	3-Chloro-2-Fluoro-5-Hydroxypyridine
CAS No.	209328-72-3
Molecular Formula	C5H3ClFNO
Molecular Weight	147.53 g/mol
Synonyms	5-Hydroxy-3-chloro-2-fluoropyridine; 2-Fluoro-3-chloro-5-hydroxypyridine; 3-Chloro-2-fluoro-5-pyridinol; 2-Fluoro-3-chloro-5-pyridinol; 5-Pyridinol, 3-chloro-2-fluoro-; 3-Chloro-2-fluoropyridin-5-ol; CFHP; CAS 209328-72-3
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2-Fluoro-5-Hydroxypyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.