Description

Spiro[1H-Indene-1,4'-Piperidine]-1',3-Dicarboxylic Acid, 1,1-Dimethyl Ethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is primarily sought by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of proprietary drug candidates and novel chemical entities.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry Development: Serves as a standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Academic & Contract Research: Utilized in university and CRO laboratories for investigating new synthetic methodologies and heterocyclic chemistry.
• Reference Standard: Employed as an analytical standard for quality control and method validation in API manufacturing.

Basic Information

Item	Details
Product Name	Spiro[1H-Indene-1,4'-Piperidine]-1',3-Dicarboxylic Acid, 1,1-Dimethyl Ethyl Ester
CAS No.	209128-15-4
Molecular Formula	C21H27NO4
Molecular Weight	357.45 g/mol
Synonyms	1',3-Di-tert-butyl spiro[indene-1,4'-piperidine]-1',3-dicarboxylate; tert-Butyl 1',3-dioxo-1',3',4',9'-tetrahydrospiro[indene-1,4'-piperidine]-1'-carboxylate; Spiro[indene-1,4'-piperidine]-1',3-dicarboxylic acid, 1,1-dimethylethyl ester; 209128-15-4; 1,1-Dimethylethyl spiro[1H-indene-1,4'-piperidine]-1',3-dicarboxylate
EINECS	Contact for details

Quality Control

Our Spiro[1H-Indene-1,4'-Piperidine]-1',3-Dicarboxylic Acid, 1,1-Dimethyl Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.