Description

1-Pyrrolidinecarboxylic Acid, 3-Hydroxy-2-Methoxy-, Methyl Ester is a high-purity synthetic intermediate of significant interest in advanced organic synthesis. This compound is valued for its unique pyrrolidine-based structure, which serves as a versatile building block for constructing complex molecules. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in classes targeting neurological and metabolic disorders.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its structural motifs can contribute to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fine Chemical Production: Employed in the synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic and Industrial Research: A valuable compound for methodological studies in organic chemistry and process development.

Basic Information

Product Name	1-Pyrrolidinecarboxylic Acid, 3-Hydroxy-2-Methoxy-, Methyl Ester
CAS No.	208648-94-6
Molecular Formula	C8H15NO4
Molecular Weight	189.21 g/mol
Synonyms	Methyl 3-hydroxy-2-methoxy-1-pyrrolidinecarboxylate; 3-Hydroxy-2-methoxy-1-pyrrolidinecarboxylic acid methyl ester; 2-Methoxy-3-hydroxypyrrolidine-1-carboxylic acid methyl ester; (2R,3S)-3-Hydroxy-2-methoxypyrrolidine-1-carboxylic acid methyl ester (for specific stereoisomer); L-threo-3-Hydroxy-2-methoxypyrrolidine-1-carboxylic acid methyl ester; A key intermediate for Linagliptin synthesis.
EINECS	Contact for details

Quality Control

Our production of 1-Pyrrolidinecarboxylic Acid, 3-Hydroxy-2-Methoxy-, Methyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity analysis, to ensure it meets the exacting standards required for pharmaceutical R&D and other critical applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.