Description

1-Trifluoromethylcyclopropane-1-Carboxylic Acid Methyl Ester is a high-value fluorinated cyclopropane building block. This compound is prized for its unique structural motif, which imparts desirable metabolic stability and lipophilicity in advanced molecular design. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries seeking to incorporate the trifluoromethylcyclopropyl group into novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and CNS-targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethylcyclopropyl moiety enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a specialized monomer or building block for synthesizing fluorinated polymers with unique surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands and catalysts for asymmetric synthesis and cross-coupling reactions.
• Life Science Research: A valuable probe and building block in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Fine Chemical Synthesis: Intermediate for the preparation of complex, high-value fluorinated compounds for various specialty chemical applications.

Basic Information

Product Name	1-Trifluoromethylcyclopropane-1-Carboxylic Acid Methyl Ester
CAS No.	208242-25-5
Molecular Formula	C6H7F3O2
Molecular Weight	168.11 g/mol
Synonyms	Methyl 1-(Trifluoromethyl)cyclopropane-1-carboxylate; Methyl 1-Trifluoromethylcyclopropanecarboxylate; 1-Trifluoromethyl-1-cyclopropanecarboxylic Acid Methyl Ester; (Trifluoromethyl)cyclopropanecarboxylic Acid Methyl Ester; Cyclopropanecarboxylic acid, 1-(trifluoromethyl)-, methyl ester; Methyl (1-(trifluoromethyl)cyclopropyl)carboxylate
EINECS	Contact for details

Quality Control

Our 1-Trifluoromethylcyclopropane-1-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are properly sealed and stored upright. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density	~1.25 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.