Description

Quinine Hemisulfate Salt Monohydrate is a high-purity pharmaceutical-grade salt of the naturally occurring alkaloid quinine. This compound is critical for its role as a key reference standard and active pharmaceutical ingredient (API) in analytical and therapeutic applications. It is primarily required by pharmaceutical manufacturers, analytical laboratories, and research institutions for quality control, method validation, and the development of antimalarial and other therapeutic formulations.

Application

• Pharmaceutical Reference Standard: Used as a primary standard in HPLC, UV-Vis, and other analytical methods for the quantification and qualification of quinine in drug substances and products.
• Active Pharmaceutical Ingredient (API): Serves as a key starting material or intermediate in the synthesis of antimalarial and antipyretic medications.
• Biochemical Research: Employed in pharmacological studies to investigate its effects on muscle function, cardiac rhythm, and as a probe for potassium channel activity.
• Beverage Industry (Bittering Agent): Used in minute quantities as a flavoring agent in tonic water and other bitter beverages, requiring high-purity grades for food safety.
• Analytical Chemistry: Utilized in the calibration of instruments and development of spectroscopic assays due to its strong, characteristic fluorescence and UV absorption.
• Quality Control Laboratories: Essential for in-house testing and compliance checks to ensure the purity and potency of quinine-based products against pharmacopeial monographs (e.g., USP, EP).

Basic Information

Product Name	Quinine Hemisulfate Salt Monohydrate
CAS No.	207671-44-1
Molecular Formula	C20H24N2O2 · ½H2SO4 · H2O
Molecular Weight	391.47 g/mol (for hemisulfate salt monohydrate)
Synonyms	Quinine bisulfate monohydrate; Quinine hydrogen sulfate monohydrate; Quinine sulfate (1:1) hemihydrate; Cinchonan-9-ol, 6'-methoxy-, (8α,9R)-, sulfate (1:1), monohydrate; Quinine monosulfate salt monohydrate; Quinine acid sulfate monohydrate; (8α,9R)-6'-Methoxycinchonan-9-ol sulfate (1:1) monohydrate
EINECS	Contact for details

Quality Control

Our Quinine Hemisulfate Salt Monohydrate is manufactured and tested under strict quality management systems. Each batch is analyzed to meet high-purity standards suitable for pharmaceutical and analytical applications. Certificates of Analysis (COA) are provided, detailing key parameters such as assay, related substances, and residual solvents. We can supply material compliant with relevant pharmacopeial standards (USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	3.5% - 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	-145° to -165° (c=1 in 0.1M HCl)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.